Malaria chemosuppression in pregnancy V. Placenta malarial changes among three different prophylaxis groups

Mutabingwa, Theonest K.

Malaria chemosuppression in pregnancy V. Placenta malarial changes among three different prophylaxis groups

dc.contributor.author	Mutabingwa, Theonest K.
dc.date.accessioned	2020-10-09T12:03:55Z
dc.date.available	2020-10-09T12:03:55Z
dc.date.issued	1993
dc.description.abstract	The effect of malaria chemoprophylaxis during pregnancy on placenta malarial changes (PMCs) was investigated in 170 tissue sections. Women of 63 sections received daily proguanil (PROG), 61 once weekly chloroquine (CQ) and 46 the two drug combination (CQ+PROG). All were residents of a malaria hyperendemic area in Muheza District, Tanzania. Supervised prophylaxis started early in pregnancy till delivery. Parasitaemias and clinical episodes were detected early and radically treated. Overall, PMCs were mostly infrequent and light viz: fibrinous deposits (98%), fibrinoid necrosis (60%), leucocytic infiltrations (59%), macrophage containing pigment (16%), and malaria parasites (8%). The type, prevalence, and severity of the PMCs in the three prophylaxis groups were comparable. This was despite the fact that PROG and CQ+PROG were prophylactically more efficacious than CQ and despite the expectation that the prevalence and severity of the PMCs would be high in the CQ group. Prompt diagnosis and effective treatment of parasitaemias in this group contributed to the low prevalence and less severity. It is concluded that effective malaria chemoprophylaxis or prompt diagnosis and effective treatment of malaria parasitaemias have significant impact on the prevalence of PMCs. Due to various operational constraints in most developing countries, chemoprophylaxis remains the only feasible broad option for malaria control in pregnancy.	en_US
dc.identifier.citation	Mutabingwa, T.K., Eling, W.M., Kitinya, J.N., Malle, L.N. and de Geus, A., 1993. Malaria chemosuppression in pregnancy. V. Placenta malarial changes among three different prophylaxis groups. Tropical and geographical medicine, 45(6), pp.274-279.	en_US
dc.identifier.uri	https://europepmc.org/article/med/8116057
dc.identifier.uri	http://hdl.handle.net/123456789/638
dc.language.iso	en	en_US
dc.publisher	Tropical and geographical medicine	en_US
dc.subject	Malaria chemosuppression	en_US
dc.subject	Malarial placenta	en_US
dc.subject	Prophylaxis	en_US
dc.title	Malaria chemosuppression in pregnancy V. Placenta malarial changes among three different prophylaxis groups	en_US
dc.type	Article	en_US