Single breath assessment of bronchial responsiveness: A Comparison with the astograph method
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Date
1991-12-12
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of UOEH
Abstract
Bronchial responsiveness to inhaled doubling concentrations of acetylcholine using the astograph
and single breathtechniques was assessed im 7 males and 11 females <meanage 22.7, SD==2,05
and 21.2, SD== 1.11},ears tbr male and femule respectivcly) healthy volunteers. Eleven (61%>
of the subjects had neither a historyof allcrgy nor whcczcs. Five<28%)haclallcrgic rhinitis
and two (11%)had asthma. Seven (64%)ef the normal subjects, all asthmatic and sulijects
with allergic rhinitis responded to inhaled acetylcholine. Respiratery conductance (Grs}and
the one second ft)rsedexpired volume (FEVD expressed as percentages of thc baselinevalues
were compared on a semilogarithmic scalc against cumulativc dosc. In most sub.iccts thc pattern of the curves showed c]ose similarities in the two methods.
'I'hebronchial sensitivity i.e.minimum cumulativc dosc of acctylcholinc justsuMcient to start a fallin the FEVL and Grs(C.i,,s and C.,t.Arespectively), showcd good corrclation (r=O,750,P<O,Ol), Thc rcsults indicatethat bronchial responsiveness can be reliably assessed using the simple single breath
methed as well as the more complex astograph mcthod.
Description
Keywords
Respiratory conductance, Astograph, Bronchial sensitivity
Citation
MASHALLA, Y.J., TOKUI, N. and KIDO, M., 1991. Single Breath Assessment of Bronchial Responsiveness: A Comparison with the Astograph Method. Journal of UOEH, 13(1), pp.1-11.