A continuing high incidence of subacute sclerosing panencephalitis (SSPE) in the Eastern Highlands of Papua New Guinea

Mgone, Charles S.

A continuing high incidence of subacute sclerosing panencephalitis (SSPE) in the Eastern Highlands of Papua New Guinea

dc.contributor.author	Mgone, Charles S.
dc.date.accessioned	2020-02-14T12:16:23Z
dc.date.available	2020-02-14T12:16:23Z
dc.date.issued	2003
dc.description.abstract	The aims of this descriptive study were to confirm the high incidence of subacute sclerosing panencephalitis (SSPE) previously reported from Papua New Guinea (PNG) and to relate SSPE to previous measles vaccination and measles illness. From February 1997 to April 1999 we diagnosed a total of 55 patients with SSPE at Goroka Base General Hospital in Eastern Highlands Province (EHP) of PNG. The diagnosis was based on high cerebrospinal fluid and serum measles virus antibody titres with progressive neurological disorder and myoclonic jerks. Of these 55 patients 42 were from EHP, including 32 whose onset was in the 2-year period 1997–1998. The annual incidence of SSPE in EHP in these 2 years was 98 per million population under 20 years of age, the highest ever reported. This incidence was more than ten times higher than the highest incidence in the prevaccine era reported from elsewhere. The mean age of onset of SSPE was 7·7 years (range 2·8–14·8 years) and the interval between measles and the onset of SSPE, where known, had a mean of 5·9 years and a range of 2·5–11·1 years. Among the SSPE patients 19 had a documented history of measles vaccination. Eight of these 19 also had documentation of previous measles illness; of these, seven were vaccinated after the development of measles and one was vaccinated 20 days before measles illness. Two non-SSPE children received vaccination twice which was documented and subsequently developed measles which was also substantiated by documentation. Two patients with SSPE yielded amplified nucleotide sequences of measles virus that were different from any of the vaccine strains. We found no evidence to implicate measles vaccination in the development of SSPE.	en_US
dc.identifier.citation	Takasu, T., Mgone, J.M., Mgone, C.S., Miki, K., Komase, K., Namae, H., Saito, Y., Kokubun, Y., Nishimura, T., Kawanishi, R. and Mizutani, T., 2003. A continuing high incidence of subacute sclerosing panencephalitis (SSPE) in the Eastern Highlands of Papua New Guinea. Epidemiology & Infection, 131(2), pp.887-898.	en_US
dc.identifier.other	DOI: 10.1017/S0950268803008999
dc.identifier.uri	http://hdl.handle.net/123456789/223
dc.language.iso	en	en_US
dc.publisher	Epidemiology & Infection	en_US
dc.subject	Subacute sclerosing panencephalitis	en_US
dc.subject	The Eastern Highlands of Papua New Guinea	en_US
dc.title	A continuing high incidence of subacute sclerosing panencephalitis (SSPE) in the Eastern Highlands of Papua New Guinea	en_US
dc.type	Article	en_US