Dihydroartemisinin-Piperaquine effectiveness for seasonal malaria chemoprevention In settings with extended seasonal malaria transmission in Tanzania
| dc.contributor.author | Mwaiswelo, Richard O. | |
| dc.date.accessioned | 2024-02-01T12:00:26Z | |
| dc.date.available | 2024-02-01T12:00:26Z | |
| dc.date.issued | 2024-01-25 | |
| dc.description.abstract | Effectiveness of dihydroartemisinin‑piperaquine (DP) as seasonal malaria chemoprevention (SMC) was assessed in Nanyumbu and Masasi Districts. Between March and June 2021, children aged 3–59 months were enrolled in a cluster randomized study. Children in the intervention clusters received a monthly, 3‑days course of DP for three consecutive months regardless of malaria infection status, and those in the control clusters received no intervention. Malaria infection was assessed at before the first‑round and at 7 weeks after the third‑round of DP in both arms. Malaria prevalence after the third‑round of DP administration was the primary outcome. Chi‑square tests and logistic regression model were used to compare proportions and adjust for explanatory variables. Before the intervention, malaria prevalence was 13.7% (161/1171) and 18.2% (212/1169) in the intervention and control clusters, respectively, p < 004. Malaria prevalence declined to 5.8% (60/1036) in the intervention clusters after three rounds of DP, and in the control clusters it declined to 9.3% (97/1048), p = 0.003. Unadjusted and adjusted prevalence ratios between the intervention and control arms were 0.42 (95%CI 0.32–0.55, p < 0.001) and 0.77 (95%CI 0.53–1.13, p = 0.189), respectively. SMC using DP was effective for control of malaria in the two Districts. Trial registration: NCT05874869, https://clinicaltrials.gov/ 25/05/2023 | en_US |
| dc.identifier.citation | Mwaiswelo, R., Ngasala, B., Chaky, F., Molteni, F., Mohamed, A., Lazaro, S., Samwel, B. and Mmbando, B.P., 2024. Dihydroartemisinin-piperaquine effectiveness for seasonal malaria chemoprevention in settings with extended seasonal malaria transmission in Tanzania. Scientific Reports, 14(1), p.2143. | en_US |
| dc.identifier.uri | 10.1038/s41598-024-52706-z | |
| dc.identifier.uri | http://hdl.handle.net/123456789/1322 | |
| dc.language.iso | en | en_US |
| dc.publisher | Scientific Reports | en_US |
| dc.subject | Dihydroartemisinin-piperaquine | en_US |
| dc.subject | Malaria chemoprevention | en_US |
| dc.subject | Tanzania | en_US |
| dc.title | Dihydroartemisinin-Piperaquine effectiveness for seasonal malaria chemoprevention In settings with extended seasonal malaria transmission in Tanzania | en_US |
| dc.type | Article | en_US |