Characterization of Benign Lesions and Carcinomas of the Female Breast in a Sub- Saharan African Population

Simple item page
dc.contributor.authorMbembati, Naboth A.
dc.date.accessioned2020-07-17T09:00:02Z
dc.date.available2020-07-17T09:00:02Z
dc.date.issued1998
dc.description.abstractCarcinoma of the breast is the second most frequent tumour in African females. Breast carcinomas in African females appear about a decade earlier and follow a more aggressive clinical course than those in developed countries. To elucidate this difference we investigated 63 biopsied benign lesions of the female breast for their potential to malignant progression. We also performed histologic typing and grading of 184 female breast carcinomas received at the Muhimbili University Hospital in Dar es Salaam, Tanzania. Fibrocystic disease and fibroadenomas were the most frequent lesions. The majority of patients with fibrocystic disease had no proliferative lesion and thus were not at a significantly increased risk of developing breast carcinomas. For fibroadenomas, no indication for precancerous lesions was found. The vast majority of breast carcinomas investigated were invasive. As a striking feature, the majority of those studied (66%) were of the non-special type (NST), displaying a more aggressive behaviour than the remaining tumours of the special type (ST). In the group of ST tumours, cribriform types constituted 41 % of the cases which may be a special feature of the carcinomas in African females. Among the NST, the tumours were either of grade II or grade III, whereas in ST, 25% of the cases were of grade I. Since histology observed in this study is comparable to that seen in patients from the Western society, late hospital presentation with advanced tumour stages may be a major reason for differences in clinical behaviour between African and Western females. A genetic factor, however, may be an important contributing factor.en_US
dc.identifier.citationMbondel, M.P., Amir, H., Mbembati, N.A., Holland, R., Schwartz-Albiez, R. and Kitinya, J.N., 1998. Characterisation of benign lesions and carcinomas of the female breast in a sub-Saharan African population. Pathology-Research and Practice, 194(9), pp.623-629.en_US
dc.identifier.otherhttps://doi.org/10.1016/S0344-0338(98)80097-6
dc.identifier.urihttp://hdl.handle.net/123456789/533
dc.language.isoenen_US
dc.publisherPathology-Research and Practiceen_US
dc.subjectBreast carcinomaen_US
dc.subjectCancer progressionen_US
dc.subjectEast Africaen_US
dc.titleCharacterization of Benign Lesions and Carcinomas of the Female Breast in a Sub- Saharan African Populationen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Characterization of Benign Lesions and Carcinomas of the Female Breast in a Sub.pdf
Size:
21.47 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Journals

Total Collections: 1