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Browsing Journals by Author "Nyarko, Richard O."

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    Biological Benefits of Diallyl Disulfide, A Garlic-Derived Natural Organic Sulfur Compound
    (2024-02-29) Mziray, Amir N.; Nyarko, Richard O.
    There is a possibility that diallyl disulfide and diallyl trisulfide can alleviate neuropathic pain in rats that have been subjected to CCI. The mechanisms by which these compounds alleviate pain entail an increase in the levels of H2S, BDNF, and Nrf2 in the sciatic nerve and the dorsal root ganglion (DRG). The use of garlic as a functional food and as a great source of pharmacologically active compounds is widely recognised and generally accepted. One of the most important bioactive components of garlic is called diallyl disulfide (DADS), and it possesses a number of beneficial biological effects. These capabilities include anti-inflammatory, antioxidant, antibacterial, cardiovascular protective, neuroprotective, and anticancer actions. In this review, the biological roles of DADS were reviewed in a systematic manner, and the molecular mechanisms that underlie these functions were explored. We have high hopes that this review will not only offer direction and insight into the existing body of literature, but will also make it possible for future study and the development of DADS for the intervention and treatment of other disorders.
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    Impact of Potassium Nitrate treatment and stratification on apple seed germination and seedling growth
    (World Journal of Pharmacy and Pharmaceutical Sciences, 2024-03-04) Nyarko, Richard O.; Mziray, Amir N.
    Apples are abundant in some micronutrients (including iron, zinc, vitamins C and E) and polyphenols (such procyanidins, phloridzin, and 5′-caffeoylquinic acid) that can help prevent chronic illnesses and micronutrient shortages. This review offers a current summary of the important bioactive ingredients found in apples, together with information on their potential pharmacological effects against long- term conditions like diabetes, cancer, and cardiovascular disease. The experiment's findings demonstrated that every treatment enhanced the germination of apple seeds and the growth of seedlings. Applying GA3, BAP, SA, and JA to stratified seeds will increase the rate of germination, seedling growth, and maximal PSII efficiency (Fv/Fm), among other benefits. Treatment T6, which included natural stratification and 2000 ppm KNO3, had the greatest effect on the shoot-root characteristics, germination rate, and survival rate of the seedlings when compared to the other treatments. Thus, T6, a naturally stratified medium containing 2000 ppm of KNO3, is a prospective therapy to improve general seedling development and apple seed germination.